The Santa Iglesia Concatedral de Santa María (S.I.C. de Santa María) is the most important Christian temple in the city of Cáceres.

José Ramón Mélida indicates that it is the oldest church in the city, as it was completed between the 15th and 16th centuries on top of a 13th century construction of Mudejar style with a wooden roof.

Made entirely of granite ashlars, its style can be considered transitional Romanesque to Gothic.

It has two Gothic doorways, the Gospel doorway, opposite the Episcopal palace, with fine archivolts and a modern image of the Virgin in the tympanum, and the main doorway, at the foot, where the coat of arms of Orellana and the Romanesque corbels of the cornice stand out.

The church has a single Renaissance tower, with three sections and a rectangular floor plan, crowned by four flameros, where storks' nests now stand; it was built between 1554 and 1559 by Pedro de Ibarra.

On the west corner of this tower is a statue of San Pedro de Alcántara, built in 1954 by the Extremaduran sculptor Enrique Pérez Comendador.

Within the whole complex, the Plateresque main altarpiece stands out, made between 1547 and 1551 by Guillén Ferrant and Roque Balduque in Flanders pine and unpolychromed cedar, in the Extremaduran style. It is divided into three sections and five streets, with sculptures in high relief and complete intermediate figures of the apostles; the central street shows motifs related to the Virgin and the infancy and passion of Jesus. The most important carving is the Assumption of the Virgin, in the centre of the second section.