The Holy and Apostolic Church Cathedral of Cádiz is the episcopal see of the diocese of Cádiz and Ceuta, in Spain.

It is a baroque and neoclassical building. Construction began in 1722 and was not completed until 28 November 1838. Economic crises caused the cathedral to have a varied style, due to the French invasions and the subsequent loss of power over America.

It is called the "Santa Cruz sobre el Mar" or "Santa Cruz sobre las Aguas", although the people of Cadiz call it the New Cathedral as opposed to the Old Cathedral, built in the 16th century over the old Gothic cathedral commissioned by Alfonso X the Wise, and which today serves as a parish church.

The decision to replace the old cathedral with a new one was due to two main circumstances: the poor state of conservation of the former, and the desire to have a more monumental and representative space in keeping with the importance that Cadiz had acquired with the transfer of the Casa de Contratación to this city from Seville in 1717.

During the 116 years of its construction, the building's design underwent changes in the fashions and tastes of different architects, which explains the combination of different styles: mainly Baroque, Rococo and Neoclassical.

It was Bishop Domingo de Silos Moreno who blessed it in 1838. Due to the delay in the works, many parts of the temple were exposed to the rigours of the weather. This and the very location of the building next to the sea has caused a disease in the stone that causes it to crumble little by little; this is why the vaults of the temple are covered by nets that prevent the debris from falling to the ground.

The church has a Latin cross plan and three naves, with a transept topped by a dome and a large pentagonal ambulatory. The interior space is delimited by sets of Corinthian columns raised on plinths. The roof is made up of vaulted ceilings in most of the building, many of which are richly decorated with sculptural decoration in bas-relief.