The Santa Iglesia Catedral de Santa María, known as the Cathedral of Murcia, is the main temple and seat of the Diocese of Cartagena. It is located in the old town of the city of Murcia, in the Plaza del Cardenal Belluga.

It was during the bishopric of Fernando de Pedrosa (1383-1402) that the works of the current temple began.

In 1385 the foundations began, and in 1388 the first stone was laid, but it was not until 1394 that the bulk of the construction work began on the building that replaced the old mosque.

The building progressed thanks to the action of effective managers such as the prelates Pablo de Santa María and Fray Diego de Bedán.

Under the Episcopate of Diego de Comontes (1446-1458) the figure of Diego Sánchez de Almazán appears as the main master of the works. During these years the vaults are closed, built on pillars of bundles of attached columns and capitals with a vegetal theme with rosettes in the keys. A large part of the forging and ironwork of the temple due to Antón de Viveros was also carried out.

Later, under the Episcopate of Lope de Ribas (1459-1478), the works entered their final stretch, being consecrated in 1467 although the bull of Paul II is dated January 24, 1465. The Door of the Apostles was completed some how many years later (in 1488).

Consecrated in 1467, it underwent several additions or occasional reforms mainly in the 16th and 18th centuries, thus integrating the original Gothic style with Renaissance, Baroque and Neoclassical additions.

Its architectural elements include the tower, 93 meters high; the main façade or imafronte, considered a masterpiece of the Spanish Baroque; and the Velez, Junterones and Trascoro chapels.

In the Main Chapel is the sepulchral urn where the heart and entrails of Alfonso X the Wise lie.