The conventual church of San Pablo is one of the most representative buildings in the city of Valladolid and a tourist attraction.

It is located in the Plaza de San Pablo, where the Royal Palace and the Pimentel Palace are also located, the so-called royal sites in past centuries.

It is attached to the San Gregorio school and close to the rest of the National Sculpture Museum headquarters.

It was built between 1445 and 1616 and belongs to the Dominican order.

Kings Felipe IV and Felipe II were baptized in this church and it was visited by Napoleon.

Between 1613 and 1616, some of the chapels in the nave and the choir were altered in the Herrerian style under the direction of Diego de Praves. According to a project designed by Francisco de Mora, Juan de Nates was entrusted with the execution of the patrons' tribune, from which the dukes heard mass, and the Doric door of the sacristy.

In the 19th century with the French invasion, Napoleonic troops desecrated the church and the convent, causing serious damage.

The progressive ruin of the complex and the various confiscation processes, especially the confiscation of 1835, ended the conventual dependencies to transform them into a prison, leaving only the church standing.

In 1968 the church suffered a fire and in the following years several restorations were carried out.

During the first years of the 21st century (specifically between 2004 and 2009), the church has undergone a comprehensive restoration.