The Casa de Pilatos is a palace belonging to the House of Medinaceli. It is one of the most emblematic buildings of Andalusian civil architecture of the 16th century, and is a combination of Italian Renaissance and Spanish Mudejar styles, the result of the different interventions that took place from the last third of the 15th century until the 17th century.

Construction of the palace began in 1483, at the initiative and wish of Pedro Enríquez de Quiñones and his second wife Catalina de Ribera, founders of the House of Alcalá. The building was erected on several plots of land that had been confiscated by the Spanish Inquisition. The death of Pedro Enríquez in 1493 left Catalina in charge of the initial configuration of the palace. Her son and grandson extended and completed the decoration of the house.

Fadrique Enríquez was a nobleman at the crossroads of the late Middle Ages and modernity, represented by the Renaissance. Between 1518 and 1520 he went on a pilgrimage to the holy city of Jerusalem, crossing the whole of Italy, where he was deeply impressed by the Renaissance art that prevailed in Italian cities. On his return he transferred the Renaissance style he had observed to the Casa de Pilatos, combining the Italian Renaissance style with the Mudejar style of Seville in the extensions he made to the palace, in which he occupied several plots of land annexed to it. Per Afán de Ribera, nephew and heir of Don Fadrique, was a great collector of art, which he collected during his time as viceroy of Naples. Between 1568 and 1571 he undertook major renovations to house his vast art collection.

After being relatively neglected in the 18th century, it was restored in the late 19th century.

In 1966, a charity ball was held here, attended by members of the nobility. Each attending family paid 5,000 pesetas, which went to the Red Cross. Grace Kelly and Jacqueline Kennedy presided over the gala.

The Casa de Pilatos is a large building complex in the historic centre of the city of Seville, in the Santa Catalina-Santiago sector. Together with the adjoining convent of San Leandro, it occupies a large part of the block between Calle Caballeriza, Calle San Esteban and Calle Imperial.

The palace is structured around two courtyards, the entrance courtyard and the main courtyard, around which the main rooms are arranged on one and two floors. On either side of this main body, occupying the rest of the plot, are two gardens of different sizes and formalisation. The so-called small garden, on the east side, and the large garden to the west. The building is dominated by sloping roofs of Arabic tiles, which are glazed in white and blue in the staircase area.